PhD defence
Genetic-Tracing of CD8+ T cell fate decisions
- L. Kok
- Date
- Wednesday 15 February 2023
- Time
- Location
-
Academy Building
Rapenburg 73
2311 GJ Leiden
Supervisor(s)
- Prof. T. Schumacher
- Prof. J. Borst
Summary
CD8+ T cells are white blood cells which are crucial in the protection against pathogens, including bacteria and viruses. When a host is infected with such pathogen, resting CD8+ T activate and give rise to various subtypes of effector and memory T cells, which are important in clearing the current infection and in providing long term protections against recurring pathogens, respectively.
The work presented in this thesis describes the discovery of novel CD8+ T cell subtypes and delineates how these newly discovered subtypes and other effector and memory CD8+ T cells subtypes are formed, through the use of genetic-tracing technologies and single cell transcriptomics. The findings described in this thesis may be of value for the development of therapeutic interventions which aim to manipulate the formation of T cell populations, including novel vaccinations strategies.
PhD dissertations
Approximately one week after the defence, PhD dissertations by Leiden PhD students are available digitally through the Leiden Repository, that offers free access to these PhD dissertations. Please note that in some cases a dissertation may be under embargo temporarily and access to its full-text version will only be granted later.
Press enquiries (journalists only)
General information
Beadle's Office
pedel@bb.leidenuniv.nl
+31 71 527 7211